CJC-1295 without DAC
Product Overview
CJC-1295 without DAC is a synthetic analogue of growth hormone-releasing hormone (GHRH) consisting of the first 29 amino acids of GHRH with four amino acid substitutions to prevent degradation by dipeptidyl peptidase IV (DPP-IV) and aminopeptidases. This modification significantly extends the peptide's half-life compared to native GHRH while maintaining its biological activity.
Molecular Specifications
- Molecular Formula: C152H252N44O42
- Molecular Weight: 3367.97 Da
- Sequence Length: 30 amino acids
- Purity: ≥98% (HPLC verified)
- Appearance: White lyophilised powder
- Solubility: Soluble in sterile water and bacteriostatic water
Structural Modifications
The key modifications include substitutions at positions 2, 8, 15, and 27 of the native GHRH sequence:
- D-Ala² substitution for enhanced stability
- Gln⁸ substitution to prevent DPP-IV cleavage
- Ala¹⁵ substitution for improved receptor binding
- Leu²⁷ substitution for increased half-life
Research Applications
This compound is utilised in various research contexts investigating:
- Growth hormone releasing hormone receptor pharmacology
- Pituitary somatotroph cell function and signalling
- Growth hormone secretion dynamics and pulsatility
- Peptide stability and degradation pathways
- Receptor-ligand interaction studies
- Comparative pharmacokinetic analysis with DAC variants
Storage & Handling
- Storage Temperature: -20°C (lyophilised), 2-8°C (reconstituted, short-term)
- Stability: 24 months lyophilised, 30 days reconstituted at 2-8°C
- Reconstitution: Use sterile water or bacteriostatic water
- Half-life: Approximately 30 minutes (shorter than DAC variant)
Quality Assurance
Each batch undergoes comprehensive analytical testing including HPLC purity analysis, mass spectrometry verification, amino acid analysis, and endotoxin testing. Certificate of Analysis provided with each shipment.
For research purposes only. Not for human consumption or therapeutic use.
