IGF-1 LR3
Product Overview
IGF-1 LR3 (Insulin-like Growth Factor-1 Long R3) is a synthetic analogue of human IGF-1, engineered with enhanced stability and bioactivity. This 83-amino acid polypeptide features an N-terminal extension of 13 amino acids and an arginine substitution at position 3, resulting in significantly reduced binding affinity to IGF-binding proteins and extended half-life compared to native IGF-1.
Molecular Specifications
- Molecular Formula: C400H625N111O115S7
- Molecular Weight: 9117.5 Da
- Sequence Length: 83 amino acids
- Purity: ≥98% (HPLC verified)
- Appearance: White lyophilised powder
- Solubility: Soluble in sterile water or bacteriostatic water
Structural Modifications
The LR3 variant incorporates critical structural modifications that distinguish it from endogenous IGF-1:
- 13-amino acid N-terminal extension derived from IGF-1 Ec domain
- Arginine substitution at position 3 (Glu→Arg)
- Reduced IGF-binding protein affinity (100-1000 fold decrease)
- Extended circulating half-life (20-30 hours vs 10-12 minutes for native IGF-1)
Research Applications
IGF-1 LR3 is utilised in various research contexts investigating growth factor signalling pathways, cellular proliferation mechanisms, and metabolic regulation studies. The compound's enhanced stability profile makes it particularly suitable for extended experimental protocols.
Storage & Handling
- Storage Temperature: -20°C (lyophilised), 2-8°C (reconstituted, short-term)
- Stability: 24 months lyophilised, 30 days reconstituted at 2-8°C
- Reconstitution: Use sterile water or bacteriostatic water
- Handling: Avoid repeated freeze-thaw cycles
Quality Assurance
Each batch undergoes comprehensive analytical testing including HPLC purity analysis, mass spectrometry verification, and endotoxin testing. Certificate of Analysis provided with each shipment.
For research purposes only. Not for human consumption or therapeutic use.
